Kev kho qhov ncauj thiab qhov ntswg
Keeb kwm ntawm Daim Ntawv Thov Enzyme Hauv Kev Kho Qhov Ncauj thiab Nasal
Txij xyoo 2006, Botai Biotechnology tau tsim los ntawm Dr. Txiv neejg, tus kws tshawb fawb Harvard postdoctoral. Tom qab rov qab los ntawm Tebchaws Meskas, nws tau coj cov kev kawm tau zoo tshaj plaws hauv enzymology rau Tuam Tshoj thiab tsim lub tuam txhab.
Peb tau tsim ib pab neeg R&D cov neeg tseem ceeb tshaj kaum tus kws tshaj lij, tsom mus rau kev rho tawm, kev txhim kho thiab kev siv Mn-SOD manganese superoxide dismutase. Peb qhov kev tshawb fawb tseem ceeb yog los txhawb nqa nws cov haujlwm siab thiab siab purity hauv kev siv tswv yim.
Feem ntau cov enzymes antioxidant hauv kev ua lag luam poob kev ua haujlwm thaum lub sijhawm thov, tsis xa cov txiaj ntsig tiag tiag tiv thaiv dawb radicals rau tib neeg lub cev.
Peb qhov kev ua haujlwm siab -SOD ua rau kom cov tawv nqaij pigmentation thiab qhov chaw tsaus. Nws kuj tseem txo cov mob o nyob rau hauv lub plab zom mov, kho cov kab mob ua pa ua pa, thiab txhim kho ntau yam sub- teeb meem kev noj qab haus huv thiab mob ntev los ntawm kev tsis muaj zog antioxidant hauv lub cev.
Kev sib raug zoo ntawm Dawb radicals thiab Antioxidant Enzymes
Dawb radicals tau ntev los ua ib qho kev tshawb fawb kub hauv kev tshawb fawb txog lub neej. Reactive Oxygen Species (ROS) yog cov dawb radicals ntau tshaj plaws hauv tib neeg lub cev, feem ntau yog muaj nyob rau hauv daim ntawv ntawm cov pa dawb radicals.
Tshaj ROS ua rau lipid peroxidation, ua rau cov qauv thiab kev ua haujlwm ntawm biofilms, ua rau cov protein denaturation, hla -txuas thiab enzyme inactivation. Nws cuam tshuam nrog myocardial shock, hluav taws xob raug mob, atherosclerosis, tiv thaiv kab mob thiab ntau lwm yam kab mob.
Cov dawb radicals ntau dhau ua rau muaj kev cuam tshuam oxidative, ua rau tib neeg cov ntaub so ntswg thiab hlwb ua rau, thiab ua rau kev laus sai - qhov no yog qhov zoo- paub txog kev laus dawb radical txoj kev xav tau los ntawm Harman.
Oxidative stress induces oxidative kev puas tsuaj rau biomolecules, tsim endogenous puas tsuaj -Txoj kev Molecular Patterns (DAMPs) thiab tso tawm cytokines. Cov no ua rau cov kev taw qhia qis qis xws li NF-κB, JAK, STAT thiab MAPK, ntxiv tso tawm cytokines thiab chemokines, nrhiav cov kab mob inflammatory thiab ua rau lub cev mob ntev.
Raws li kev sib txuas ntawm oxidative kev nyuaj siab, o thiab kev laus, cov kws tshawb fawb tau muab tso rau hauv oxidative -inflammatory aging txoj kev xav, lees paub tias oxidative kev nyuaj siab yog ib qho tseem ceeb ntawm inflammatory aging.
Superoxide Dismutase (SOD) muaj nyob hauv cov kab mob. Raws li ib qho tseem ceeb tsis muaj oxygen dawb radical scavenger, nws plays lub luag haujlwm tseem ceeb hauv kev tiv thaiv oxidative puas tsuaj.
Raws li khi hlau ions, SOD muab faib ua plaub hom: Cu/Zn-SOD, Fe-SOD, Mn-SOD thiab Ni-SOD. Kev tshawb fawb ua pov thawj tias SOD tshem tawm cov pa dawb radicals zoo, tshem tawm ntau yam mob thiab tiv thaiv hluav taws xob puas tsuaj. Ntawm lawv, Mn-SOD nta qhov ruaj khov siab tshaj plaws thiab qis tshaj toxicity.
Nyob rau hauv mitochondrial oxidative phosphorylation electron thauj system, oxygen yog qhov kawg electron txais. Thaum hloov hluav taws xob tsis tiav, siab - kev ua haujlwm ROS raug tsim tawm. ROS tawm tsam lipids, proteins thiab DNA, ua rau neurodegeneration, aging, cancer, pulmonary fibrosis thiab vascular kab mob, thiab nws kuj yog ib qho tseem ceeb inducer ntawm o.
Kev mob yog lub cev tiv thaiv kab mob, raug mob thiab ischemia. Cov lus teb tsis zoo ua rau muaj ntau yam kab mob, nrog rau leukocyte tsiv teb tsaws thiab infiltration raws li cov yam ntxwv pathological.
Antioxidant enzymes yog cov tseem ceeb regulators ntawm o. Mitochondrial Mn-SOD yog thawj kab ntawm kev tiv thaiv cov pa dawb radicals; nws cov haujlwm ncaj qha txiav txim siab dawb radical scavenging efficiency thiab kho qhov mob.
Hauv cov tsiaj txhu, Mn-SOD nyob hauv mitochondria, tswj cov pa oxygen thiab tiv thaiv mitochondria los ntawm kev puas tsuaj dawb radical. Cov kev tshawb fawb pom tias Mn-SOD muaj feem cuam tshuam nrog kev mob thiab cellular senescence.
Mn-SOD noob tsis muaj peev xwm ua rau muaj kev puas tsuaj loj mitochondrial thiab txawm tias tus menyuam hauv plab tuag, thaum Mn-SOD ntxiv tuaj yeem ua rau muaj sia nyob ntev.
Mn-SOD xav tias yuav dhau los ua cov tshuaj tiv thaiv ntuj tshiab - mob thiab tiv thaiv - cov khoom qub rau kev kho mob.
Kev saib xyuas qhov ncauj thiab qhov ntswg yog ib qho ntawm cov khoom siv.Tab sis tsis txwv
Nws kuj tseem ua haujlwm rau kev mob tshwm sim los ntawm exogenous irritants, nrog rau cov uas tshwm sim los ntawm cov khoom lom, cov yam ntxwv ntawm lub cev, cov tshuaj exogenous, los yog lawv cov teebmeem ua ke.
Cov kab mob tshwm sim los ntawm cov kab mob lom neeg hais txog cov nqaij mos thiab cov kab mob tshwm sim los ntawm cov kab mob, kab mob, rickettsiae, protozoa, fungi, spirochetes thiab parasites.
Raws li rau kev mob tshwm sim los ntawm cov tshuaj exogenous, nws txhim kho cov kev tsis zoo tshwm sim los ntawm cov khoom siv hluav taws xob, muaj zog acid, muaj zog hauv paus, muaj zog oxidants, cawv thiab tshuaj lom neeg. Nws yog qhov tshwj xeeb tshaj yog tsim nyog rau kev txo qis cawv lossis tshuaj yeeb tshuaj -induced hepatitis thiab o tshwm sim tom qab kws khomob.
Tsis tas li ntawd, cov khoom no muaj txiaj ntsig zoo rau cov teeb meem ntawm daim tawv nqaij, xws li tinea manus thiab pedis, folliculitis, hu rau dermatitis, eczema, urticaria, neurodermatitis thiab seborrheic dermatitis, thiab kuj yog tus phooj ywg rau kev kho tus menyuam mos eczema.
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Xaiv Bio-Crm, Xaiv qhov kev lees paub zoo
Peb yog ib qho ntawm cov kws tshaj lij kev kho qhov ncauj thiab qhov ntswg manufacturers thiab cov muag khoom hauv Suav teb. Nrog ib pab neeg tsim khoom, peb muaj peev xwm ua tau raws li qhov xav tau ntawm feem ntau ntawm peb cov neeg siv khoom. Txais tos rau kev lag luam wholesale kev cai ua qhov ncauj thiab qhov ntswg los ntawm peb lub hoobkas.